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Opening of the VGCCs evoked by membrane depolarisation, produced by increasing extracellular K + ([K + ] o ) to 70 mmol/l, stimulated glucagon secretion by over threefold, and this response was reduced by 60% by GLP-1(936) (Fig

Angiotensin IV (Val 1 -Tyr 2 -Ile 3 -His 4 -Pro 5 -Phe 6 ) is an endogenous hexapeptide fragment of the renin-angiotensin system, historically considered a metabolite of angiotensin II but subsequently shown to have independent procognitive activity in rodent models