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Then we had Herman Pontzer on and we talked about metabolic adaptation from the burn side, right the reason you can't marathon your way to weight loss because your body's just going to adjust

Cell 187(15):38293853 Wolfe MM, Boylan MO, Chin WW (2025) Glucose-dependent insulinotropic polypeptide in incretin physiology: role in health and disease

The hormone your body already makes GLP-1 (derived from glucagon-like peptide-1) is produced by specialized cells called L-cells located primarily in your intestines

A 2025 eClinicalMedicine meta-analysis (18 RCTs, 3,771 participants) found an average regain of 5.63 kg after discontinuation in adults with obesity

The syringe you choose determines whether that happens correctly

Can you use SingleCare for GLP-1s if on Medicare