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Always complete a medical consultation, disclose all medications, and monitor initial treatments for any adverse effects [5] [6]

In mouse models of insulinresistance treatment, FGF21 increased energy expenditure, reduced plasma circulating levels of glucose, improved liver steatosis, and improved both leptin and insulin sensitivity (71, 72)

Kil J, Lobarinas E, Spankovich C, et al

We thank Ms Colleen Pisaneschi for editing the manuscript and Sigma-Tau (Pomezia, Italy) for the gift of acetyl-L-carnitine

A meta-analysis in 2020 also demonstrated that NAC had comparable effects to metformin in improving serum LH levels, the LH/FSH ratio, and fasting insulin in women with PCOS [46]