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The gamma-glutamyl cycle should be considered not as a mechanism for amino acid transport but rather a generator of extracellular signals, gamma-glutamyl amino acids, that are converted intracellularly to 5-oxoproline, which activates uptake and/or metabolism of amino acids (74, 75)

doi:10.1172/JCI29444

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Receptor-mediated endocytosis in cancer Cancer cells use receptor-mediated endocytosis for the selective internalization of specific cell surface proteins

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NAC, though widely used, has relatively low bioavailability, while NACA, due to its greater membrane permeability, can be used in lower concentrations and shows greater antioxidant potential