Children aged 412 years were diagnosed with ASD according to DSM criteria, both boys and girls were included, and the study explicitly excluded participants with major psychiatric comorbidities such as ADHD, depressions, bipolar disorder, anxiety disorders, epilepsy, severe intellectual disabilities, or recent antipsychotic use, ensuring relative homogeneous sample focused on irritability
doi: 10.1186/s11689-018-9237-x 57
Although many of these studies have based their findings on peripheral markers of abnormal metabolism, many studies have documented some of these same abnormalities in the brain of individuals with ASD, including mitochondrial dysfunction and oxidative stress (30) and one study has demonstrated a link between oxidative stress, inflammation, and mitochondrial dysfunction in the brain of individuals with ASD (23)
Alternatively, carnitine acetyltransferase (CAT) catalyzes the transfer of short-chain fatty acids from CoA to carnitine
Therefore, additional studies focusing on long-term supplementation and its longitudinal effect on the TMAO metabolism and cardiovascular system are needed
Apto para: Se recomienda para personas de peso normal o ligeramente superior, pero que tienen reas localizadas de grasa o celulitis y para personas que desean optimizar y mantener los resultados de un tratamiento de contorno o modelado corporal
