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In addition, to help decrease neuroinflammation, a key factor driving PD pathogenesis, GLP-1 RAs modulate immune cell activity and suppress the release of proinflammatory cytokines, such as TNF-, IL-6, and IL-1, all of which play a major role in neuroinflammation

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Epitalon and the bigger picture Epitalon, a tetrapeptide (Ala-Glu-Asp-Gly), does not function as a direct antidepressant

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4 Novel therapeutic approaches of NO signaling in CRC The therapeutic potential of targeting NO signaling and its associated molecular pathways has attracted significant attention in CRC research in recent years (119, 120)