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Curr Mol Med

PMID: 38432109 J Cancer Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway

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A second mechanism is based on the competitive inhibition of the GSSG binding site by G-S-G and by the metal glutathione conjugate, as depicted in Scheme 11

This has led to interest in NAC for conditions like systemic lupus erythematosus (SLE), where a small RCT found that NAC (2.4-4.8 g/day) improved disease activity scores and reduced anti-dsDNA antibody levels (Lai et al., Lupus, 2012) [42]