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How do we manage side effects

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AICAR and metformin were from Cayman Chemical (Ann Arbor, MI)

Microdosing protocols using 1mg or lower require even greater precision in reconstitution and vendor weight accuracy

Once nausea resolves (typically by week 48), most patients tolerate ice cream without additional side effects, though portion sizes remain naturally small due to appetite suppression

A Cochrane review examining probiotics for constipation found modest benefits for certain strains, with small improvements in stool frequency and consistency