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doi: 10.1038/nature20791 279 Martinez-OutschoornUELinZWhitaker-MenezesDHowellALisantiMPSotgiaF
MM: Conceptualization, Data curation, Supervision, Writingoriginal draft, Writingreview and editing
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Does tirzepatide injection work faster than oral tirzepatide for first-month weight loss
However, in keeping with our data on receptor pharmacology, increasing the dose to 30 nmol kg 1 , tenfold higher than maximal doses from our studies, shows that tirzepatide does have insulinotropic activity in Glp1r -/- mice or in the presence of a GLP-1R antagonist 5 , demonstrating that tirzepatide can engage the GIPR in mouse beta cells at sufficiently high concentrations
