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Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia

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Prior to regulatory approval, the SCALE, phase III trials demonstrated a sustained 2-year weight loss with liraglutide treatment as an adjunct to diet and exercise in non-diabetic participants (140, 141), strengthening the argument that effects are largely independent of glycaemic modulation

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Again, the findings backed up the idea that these genetic variants lead to GLP-1 resistance: Those who had the standard PAM gene variants reacted better to GLP-1 medication than those who didn't