Aside from AsPC-1, LUNA-18 exhibited significant cytotoxic activity (IC50=0.17-2.9nM) against cell lines with KRAS gene mutations, such as LS180 (colorectal cancer, KRASG12D), GSU (gastric cancer, KRASG12D), NCI-H441 (non-small cell lung cancer, KRASG12V), NCI-H2122 (non-small cell lung cancer, KRASG12C), and MiaPaCa-2 (pancreatic cancer, KRASG12C)
The most common mutation in this gene that results in hyperhomocysteinemia is a C to T change at nucleotide position 677 (C677T)
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This 2-month discontinuation recommendation reflects semaglutide's pharmacokinetics rather than evidence of direct fertility impairment
The 5mg dose is the first clinically therapeutic dose, and the change in appetite for many patients is described as transformative