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Early PARP-1 activation may delay apoptosis by suppressing Caspase-3, but prolonged NAD + depletion forces cells into AIF-dependent death [81]

As GSH patrols the cellular environment and puts out oxidative free radical fires, it becomes oxidized and inactive, thus turning into GSSG

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Upon arrival, they fuse with cell membranes, injecting GSH intracellularly like a precision airstrike

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2 Mitochondrial dysfunctions in kidney diseases 2.1 Mitochondrial homeostasis imbalance Mitochondrial quality control (MQC) is an elaborate mechanism to maintain homeostasis, ensuring the enough numbers of functional mitochondria (Pickles et al., 2018