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some patients notice improved sleep early Months 1-3: Gradual improvements in energy, recovery, and sleep quality Months 3-6: Body composition changes become measurable

Increases in serum creatinine of greater than or equal to 50% over baseline occurred in 2% of adult subjects receiving phentermine and topiramate extended-release 7.5 mg/46 mg and 2.8% receiving phentermine and topiramate extended-release 15 mg/92 mg, compared to 0.6% receiving placebo

This evidence challenges the conventional approach of delaying medication intervention and offers practitioners new options for tailoring obesity treatment to individual response patterns

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Am J Pathol (2015) 185(1):18596.10.1016/j.ajpath.2014.09.010 97 Lehrskov-SchmidtLLehrskov-SchmidtLNielsenSTHolstJJMllerKSolomonTP

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