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These effects are shaped by specific microbial taxa rather than overall diversity, highlighting how targeted changes in the microbiome can influence gut-brain communication

Hare, D

however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development

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It belongs to a class of medications known as GLP-1 receptor agonists, which also includes Ozempic, Mounjaro, Zepbound, Trulicity, Rybelsus, Saxenda and Victoza