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Inhibition of GCH1 reduced BH4 and resulted in enhanced erastin-induced iron accumulation and lipid peroxidation, thereby enhancing ferroptosis sensitivity, while BH4 supplementation suppressed ferroptosis-related changes caused by GCH1 downregulation

Choline is considered a lipotropic, which helps break down accumulating fats in the liver lowering cholesterol deposits

Flohe L, Gunzler WA, Schock HH

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Kwong, L

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