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If undiagnosed, diabetes can cause cardiovascular diseases, neuropathy (nerve damage), nephropathy (kidney damage), retinopathy (eye disorders), and even lower-limb amputation [1]

10.1210/clinem/dgac080 22 LiewZ.RitzB.RebordosaC.LeeP

By binding and activate GLP-1 receptors, GLP-1 agonists, and endogenous GLP-1 are capable to reduce blood glucose levels helping T2DM patients to reach a glycemic control

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Link: Wilding, J

Its mature domain binds and activates the type 1 IGF receptor (IGF-1R), triggering the canonical downstream cascades principally the PI3K/Akt/mTOR axis that governs protein synthesis and the Ras/ERK axis associated with proliferation