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Sua capacidade de estimular a angiognese (via VEGF) levanta a questo de um eventual risco no contexto de patologias onde a neovascularizao indesejvel, como certos cnceres

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Relative mRNA expression of Gclm (p = 0.0026), Hmox1 , Nqo1 , and Slc7a11 (d) and representative immunohistochemistry of indicated proteins (e) in Gclc WT and Gclc KO tumors (n = 6 representative from 3 independent experiments)