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244 Therefore, a complex regulatory mechanism may underlie the modulation of TMAO metabolism by statins, necessitating further research to clarify the precise pathways involved and their clinical implications (Table 8)

doi: 10.1186/1475-2891-13-79 41

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3 , 4 , 5 Yet the increasing number of pharmacological alternatives to surgical interventions introduces distinct challenges, including high costs, limited long-term outcome data and potential side effects that can range from minimal to life-threatening, some of which are slow to emerge

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