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Standard antihistamines are not serotonergic and do not typically contribute to this risk

It manages energy metabolism and physical performance

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For example, E50K mutated OPTN induced impairment of autophagy that led to cell death in RGC-5 cell lines 28 , and rapamycin, an autophagic inducer, protected RGCs in E50K OPTN overexpressed rats in vivo 29

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Consistent with these results, mouse embryonic fibroblasts (MEFs) lacking the clock activator Bmal1 displayed reduced CI respiration, whereas MEFs lacking the repressors Cry1 and Cry2 exhibited increased CI respiration (Fig