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doi: 10.1210/jc.2009-2556 228 CoopmansECKorbonitsM
The peptide functions as a precision senolytic agent by competing with endogenous FOXO4 for p53 binding, releasing the tumor suppressor protein to trigger apoptosis specifically in cells that have accumulated the senescence-associated secretory phenotype (SASP) markers
The results of the study summarized below are presented in more detail in a comprehensive review of the literature, several issue briefs, and this final report ( II
This represents one of the longer longitudinal observations in the peptide longevity research space
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