For those under the age of 21, the legal limit ranges from 0.01% to 0.05%
However, pigment-producing cells in phototypes IV to VI are more reactive, meaning they produce melanin more readily in response to stimuli like UV, inflammation, or chemical irritation
For example, some striatal DA neurons co-load GABA via VMAT2, albeit into separate pools of DA and GABA vesicles that seem to be regulated somewhat distinctly within the same neurons (Zych and Ford, 2022)
An analog of SP increased the excitability of the ventral pallidum which is interesting since inactivation of the ventral pallidum is thought to prevent drug- or stress-induced reinstatement (Napier et al., 1995
doi:10.3390/ijms19071987 Park JR, Lee H, Kim SI, Yang SR
This raises the question as to whether clinical practice would need to follow a specific protocol. So, that means theres more information needed about how the effectiveness of these substances is influenced by their environment