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In a follow-up publication the next year, the Copenhagen group evaluated their isolated GLP-1 (736), along with synthetic GLP-1 (736) amide 4 from a commercial source, and reported modest (two to four-fold) increases in insulin production in the perfused pig pancreas when exposed to nanomolar concentrations of these peptides [45], a significant but less dramatic effect than the earlier MGH findings in rats [40]

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For patients without diabetes using GLP-1 medications solely for weight loss, the glucose-raising effect is less clinically urgent but still represents an undesirable metabolic signal

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