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It has been proposed that GIP regulates inflammation and leukocyte adhesion through endothelin 1 while promoting vasodilation via nitric oxide secretion [109]

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GHK as a copper-binding peptide GHK binds copper(II) through coordination by the N-terminal amino group of glycine, the imidazole nitrogen of histidine, and the deprotonated amide nitrogen of the Gly-His peptide bond, forming a stable square-planar (or square-pyramidal) complex