Indeed, no significant decreases in ascorbic acid or -tocopherol levels were observed in the brains of AD and PD patients [129,133,134]
A systematic literature search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, EBSCO, and OVID databases (until 25 October 2024), with PROSPERO registration number CRD42024602837
Abbreviations ASL: Airway surface liquid ALI: Airliquid interface COPD: Chronic obstructive pulmonary disease WHO: World health Organization PM: Particulate Matter AED: Aerodynamic equivalent diameter ROS: Reactive oxygen species RNS: Reactive nitrogen species NAC: N-acetylcysteine hNEC: Human nasal epithelial cell poly I:C: Polyinosinic:polycytidylic acid HDM: House dust mite BaP: Benzo[a]pyrene CYP27B1: 1-Hydroxylase RSV: Respiratory syncytial virus hBEC: Human bronchial epithelial cell LPS: Lipopolysaccharide BALF: Bronchoalveolar lavage fluid TH17: T helper 17 DEP: Diesel exhaust particle EMT: Epithelial-mesenchymal transition CSE: Cigarette smoke extract GSH/GSSG: Glutathione (reduced/oxidized) CF: Cystic fibrosis IPF: Idiopathic pulmonary fibrosis References Yang W

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Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia