Not losing weight despite dose increases
Semaglutide and tirzepatide are administered via weekly subcutaneous injection
Insurance Coverage Reality (2026) Per KFF's 2025 Employer Health Benefits Survey: About 40% of US employer plans cover GLP-1s for obesity
(Click through for more ways to activate your body's brown fat.) Why GLP-1 boosters have taken the weight-loss world by storm The active ingredient in both Ozempic and Wegovy is called semaglutide and belongs to a class of drugs known as GLP-1 agonists
Thats why injections were used in all the major trials to test the efficacy of GLP-1s: STEP (semaglutide), SURMOUNT (tirzepatide), and SCALE (liraglutide)
These findings support the idea that some patients may have partial biologic resistance to incretin-based therapies, said Robert Glatter, MD, attending physician in the Department of Emergency Medicine at Lenox Hill Hospital in New York City, and Assistant Professor of Emergency Medicine at Zucker School of Medicine at Hofstra/ Northwell
