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Comparing GLP-1 Offerings Josie offers the following: Compounded GLP-1 Injections Compounded GLP-1 Oral Dissolvable Tablets Compounded GLP-1 + GIP Injections Compounded GLP-1 + GIP Oral Dissolvable Tablets Microdose Compounded GLP-1 Injections Microdose Compounded GLP-1 + GIP Injections Month-To-Month, 3, 6, or 12-Month Plans Hers offers the following for weight loss: Brand-name GLP-1 injections - Wegovy, Zepbound, Ozempic, Mounjaro Brand-name GLP-1 oral tablets - Wegovy pill, Ozempic pill Cash pay only - no insurance Requires Hers Weight Loss Membership ($39 first month, then $149/mo) BMI Requirements At Josie, our providers look at more than BMI when reviewing patients for compounded GLP-1 medications

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Semaglutide (Ozempic, Wegovy, Rybelsus) Market, 2021-2033 (USD Million) 4.5

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Mitochondria and their viability are primarily dependent on the level of production of cytosolic reactive oxygen species (ROS), the calcium balance, and adenosine monophosphate protein kinase (AMPK) signaling (Walker and Moraes, 2022)