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in fact, their weight reduction was less pronounced than that of those on the lower dose

In addition, mitochondria also produce a large amount of ROS during normal metabolism and the generation of cellular energy via the electron transport chain, leading to cell and tissue damage [36]

Mapping the growth hormone-Stat5b-IGF-I transcriptional circuit

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Thyroid-Stimulating Hormone Receptor (TSHR) Gene : Mutations in the TSHR gene, which encodes the receptor for thyroid-stimulating hormone (TSH), can lead to the production of autoantibodies that stimulate the thyroid gland to produce excessive amounts of thyroid hormones

ROS are products of normal physiological activities and are a general term for a class of chemically active molecules and ions with high oxidative activity, which play important roles in cell signaling and tissue homeostasis ( 2 - ), peroxides (H 2 O 2 and LOOH), and free radicals (HO and LO)