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People with Leber hereditary optic neuropathy should not receive cyanocobalamin

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The aim of the current study was to estimate the Cu(II)-binding affinities of major serum copper proteins (HSA, CP and 2M) in comparison with LMW Cu(II)-binding reference ligands including His by using an unified and direct approach, which gives thermodynamic background for understanding the distribution copper in the blood

Response: We thank the commenter for the notification that CPT code 0582T represents a Category B IDE study

In addition to migration of neuroblasts from the SVZ toward the lesion, it is also conceivable that quiescent progenitor cells in the neocortex are stimulated during an infarct and contribute to the population of DCX + cells in the perilesional zone