Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin-dependent diabetic GK (Goto-Kakizaki) rats
The effects, such as appetite suppression and blood sugar control, may weaken if doses are skipped
Environmental and lifestyle factors, including diet, exercise, and exposure to pollutants, also influence oxidative stress levels, making it difficult to develop standardized treatments
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BMC Endocr Disord 2010;10:7