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Psychiatry 64 , 645652 (2008)

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A Review on Various Uses of N-Acetyl Cysteine

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Hydroxocobalamin, in particular, is usually the recommended option as it stays in the body longer

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans