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To control it, inject a small amount of air into the vial first (about 0.5 mL) through the needle before adding water

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becomes particularly relevant, and the answer truly varies depending on a few key factors: The Underlying Cause of Deficiency: The Underlying Cause of Deficiency: Pernicious Anaemia/Malabsorption: For those with an inability to absorb B12 orally (like in pernicious anaemia), injections are typically a lifelong treatment