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In animal toxicology studies, no significant adverse effects have been observed even at doses far exceeding typical therapeutic ranges

doi:10.1210/endo.142.12.8522

Specifically, the abundances of Firmicutes (Bacillota) , Campylobacterota , Actinobacteriota , and Cyanobacteria decreased, whereas the abundances of Proteobacteria (Pseudomonadota) and Verrucomicrobiota increased ( Klebsiella pneumoniae infection may modulate the hosts immune regulatory function by altering the metabolites of the gut microbiota, such as short-chain fatty acids (SCFAs) ( Figure 1 ) However, whether gut microbiota dysbiosis is merely a consequence of pneumonia remains debated

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BHK-21 cells in 6-well plates were transfected with siRNAs using Lipofectamine RNAiMAX (13778150, Thermo Fisher)