Molecules (Basel, Switzerland) , 19 (11), 1906619077
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Popa T, Velayudhan B, Hubsch C, Pradeep S, Roze E, Vidailhet M, et al
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When used as monotherapy, tirzepatide has a very low risk of causing clinically significant hypoglycemia (less than 0.6% incidence), similar to placebo, due to its glucose-dependent mechanism of action that limits insulin secretion when blood sugar approaches normal levels
Methods: For this review, we prioritized recent evidence, focusing on reviews and meta-analyses published between 2015 and 2025, sourced from PubMed and Google Scholar