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The two oxygen atoms of the hydroxyphosphinyl group of 43 are interacting with the zinc ion whilst hydrogen bonds with Glu371 and Tyr455 essential for catalysis are created

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Steril., 2010, doi: 10.1016/j.fertnstert.2009.12.030

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through this regulated network, the family controls mitochondrial membrane integrity and BAX/BAK pore formation, thereby executing intrinsic apoptosis ( Figure 1 and Figure 2