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This article reviews the efficacy and safety of different strategies to initiate and intensify basal insulin, with focus on new fixed ratio combinations of basal insulin with GLP-1 RAs available for use in a single injection pen (insulin degludec/liraglutide and insulin glargine/lixisenatide)
For Weekly Injections (Semaglutide/Tirzepatide): There's a bit of flexibility built in
All reconstitution, dosing, and administration must be carried out by authorised trial pharmacy or clinical staff under a Clinical Trial Authorisation (CTA)
GLP-1 receptor agonists are prescribed for type 2 diabetes when other treatments are inadequate or unsuitable, according to NICE guidelines
Cao S, Shaw EL, Quarles WR, Sasaki GY, Dey P, Hodges JK et al
in the control + Sal A group, normal rats were fed on basic diet prepared for 16 weeks and were given Sal A (1 mg/kg/day, dissolved in saline, ip) for the final 4 weeks during 16-week basic diet treatment
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