Although free radical reactions are necessary for the defense mechanism of cells such as neutrophils and macrophages from immune system cells, overproduction of free radicals results in tissue damage and cell death [3]
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In addition to their fenestrated capillaries, the circumventricular organs also contain specialized cell structures called tanycytes, which send projections into the surrounding blood vessels and also into the brain parenchyma, that is, the brains functional tissue, which comprises neurons, glial cells, and collagen proteins
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