Notably, the COF nanoparticles remain off in normal tissues, with both fluorescence and PDT effects quenched, but are selectively switched on in the hypoxic tumor environment, producing strong fluorescent signals and ROS generation ( Figure 13B )
Moreover, GPX4 levels were elevated on treatment with SCLA2 and derived alkyne probes SCLA2a and SCLA2b (Extended Data Fig
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For a marathoner, failing to fuel properly means hitting the wall at 30km