Under the stimulation of growth factors, PI3Ks are recruited onto the plasma membrane to catalyze the phosphorylation of the 3-hydroxy group of PIP2 to generate PIP3, which then acts as the second messenger, recruiting PDK1 and AKT proteins onto the plasma membrane to partially activate AKT by PDK1
(PubMed) Vinceti M, Crespi CM, Malagoli C, Del Giovane C, Krogh V
Time to clinical benefit of dapagliflozin and significance of prior heart failure hospitalization in patients with heart failure with reduced ejection fraction
10.1111/acn.12016 406 SorboniS
Each has trade-offs in terms of cost, convenience, and clinical supervision
Familiarizing oneself with newly available medications and pertinent counseling information is a critical step toward helping patients effectively utilize their medications to best meet their individualized treatment goals