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Weeks 1-16 follow an initial dose escalation schedule, while the full dose is reached at week 17 of administration, as follows [5]: Weeks 1-4: 0.25mg subcutaneously once weekly

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The surgery is chosen when these issues cause severe symptoms

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Ferroptosis is characterised by increased reactive oxygen species (ROS), lipid peroxidation, iron accumulation, as well as depletion of glutathione (GSH) [47], and it has been seen in chronic bone disorders, such as OA [48-50]