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They are used under the close supervision of a healthcare professional and tailored to meet the specific needs of each individual

Yap IKS, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK: Urinary metabolic phenotyping differentiates children with autism, from their unaffected siblings and age-matched controls

Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials

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Two major caveats here: First, this was an observational study, not a randomized trial