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Looking Back on GLP-1 RAs Originally discovered in the saliva of the Gila monster, exenatide a GLP-1 RA was approved as a twice-daily injection by the FDA in 2005 for adults with type 2 diabetes

Although the precise mechanisms underlying this effect are not fully elucidated, it is thought to involve central appetite suppression, enhanced satiety, and delayed gastric emptying [77]

However, while they can be highly effective, individual results vary based on numerous factors, including diet, lifestyle, and metabolic differences

Scarpellini E, Arts J, Karamanolis G, et al