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The new EHR data suggests its absence is one of the biggest reasons routine-care patients lose more muscle than trial subjects

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GLP-1s are a bottom-up approach, using gut hormones to create a natural feeling of fullness and metabolic balance

The blue colour indicates active peptide

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Leptin is produced not only in the adipose tissue but also in the gastrointestinal tract, particularly in the stomach, where it has been shown to protect the gastric mucosa against various topical irritants and ulcerogens, acting, at least in part, via enhancement of mucosal blood flow due to increased production of nitric oxide (NO) caused by upregulation of NO synthase as well as the activation of brain-gut axis pathways (48, 49)