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Given that a function of glycolysis is consistent with the control of redox homeostasis, the data is consistent with prior studies that demonstrated that glyercol-3-phosphate can be a major contributor of substrate-fuelled mitochondrial ROS production 29

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Patients enrolled in clinical trials should discuss any new or worsening symptoms with their trial team before self-managing with additional medications, to ensure there are no interactions or contraindications relevant to their specific trial protocol

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This is why every GLP-1 medication carries a warning against use in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)