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Understanding the Roots of Pigmentation Pigmentation is determined by a substance called melanin

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The AMP genes -defensin 2/defensin-4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) are encoded by 1,25(OH) 2 D/VDR signalling in the immune cells, thus contributing to the innate immune defence (172, 173)