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The PDHB gene is located on chromosome 3p14.3 and is composed of 9 exons that generate three alternatively spliced mRNAs, each of which encodes a distinct protein isoform

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acetolactate synthase, acetohydroxy acid isomeroreductase, dihydroxyacid dehydratase, isopropylmalate synthase and isomerase, and leucine aminotransferase

Generalized anxiety disorder is associated with prolonged sleep-onset latency, frequent nocturnal awakenings, and reduced slow-wave sleep due to elevated corticotropin-releasing factor activity and hyperactivated HPA axis tone

Br J Psychiatry

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