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These observations provide a novel theoretical foundation for the treatment of OP via targeting the GM5-HT axis, indicating that suppression of gut-derived 5-HT biosynthesis may serve as a promising anabolic approach for bone health
Both SIRT1 and SIRT6 are measurably downregulated in older skin, and this downregulation correlates directly with reduced NAD+ availability
L.BalzsM.CaplaziP.et al (2011)
This is probably a reflection of the difficulties of accurate analysis at these low concentrations
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