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Gel-forming antioxidant eye drop efficacy in rd10 mice After confirming that topical delivery of NAC and NACET in gel-forming eye drops could provide functional and structural protection of photoreceptors in a chemically-induced model of ROS-driven retinal degeneration, we then sought to test efficacy in a genetically-induced model of RP

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157 While corticosteroids and other immunosuppressive agents exert broad anti-inflammatory effects, direct inhibition of NLRP3 inflammasome activation represents a more specific therapeutic strategy, potentially allowing for more effective suppression of inflammation with reduced off-target effects

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The results indicated that N-terminal modifications were particularly effective at enhancing metabolic stability