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GSEA was performed utilizing the Kyoto Encyclopedia of Genes and Genomes (KEGG) database for pathway enrichment analysis 33 , with Benjamini-Hochberg adjustment for multiple testing

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HSPB1, heat shock protein family B (small) member 1

Every patient gets a body-composition scan, included free of charge with every consultation, for every patient, on every visit

It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes

Peptide therapeutics: current status and future directions