Common side effects of semaglutide include: Nausea Vomiting Diarrhea Constipation Abdominal pain Indigestion (dyspepsia) Abdominal distension Decrease in appetite Belching (eructation) Gas (flatulence) Gastritis Gastroenteritis Viral gastroenteritis Gastroesophageal reflux disease (GERD) Gallstones (cholelithiasis) Headache Fatigue Dizziness Low blood glucose level (hypoglycemia) Severe hypoglycemia Diabetic retinopathy Bleeding in the vitreous, the gel-like substance within the eye (vitreous hemorrhage) Blindness Hair loss (alopecia) Antibody development Low blood pressure (hypotension) Drop in blood pressure when getting up from sitting or lying down (orthostatic hypotension) Less common side effects of semaglutide include: Discomfort and redness at the site of injection Inflammation of the pancreas (pancreatitis) Increase in amylase, the enzyme that helps digest carbohydrates Increase in serum lipase, the enzyme that breaks down fats Hemorrhoids Biliary tract disease Gallbladder disease Inflammation of the gallbladder (cholecystitis) Need for removal of gallbladder (cholecystectomy) Acute kidney injury Increased heart rate Skin rash Hives (urticaria) Bullous pemphigoid, a rare skin disorder with fluid-filled blisters Severe allergic reaction (anaphylaxis) Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug: Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness

The minimum 3-day spacing is maintained throughout, ensuring proper dosing intervals
Annu Rev Physiol 2014;76:53559.PubMed 4
doi: 10.3389/fendo.2021.645563 Received 23 December 2020 Accepted 19 April 2021 Published 07 July 2021 Volume 12 - 2021 Edited by Francesco Giorgino, University of Bari Aldo Moro, Italy Reviewed by Bo Ahrn, Lund University, Sweden
Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction: Implications for patients with and without recognized diabetes
Understanding these mechanisms helps explain why gastrointestinal symptoms occur and that they often improve with continued treatment