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Pre & Post Care Instructions Getting Ready for B12 Injections Avoid exposing your skin to direct sunlight for 1 week

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Sci Transl Med (2013) 5:206ra138

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Chronic sun exposure history: Skin with a longer history of significant UV exposure often has more entrenched pigmentation patterns, which can mean a longer visible timeline even with excellent internal supplementation

Topical measures include applying ice 1-2 minutes before injection to numb the area, and gentle pressure (not rubbing) for 10 seconds after